Estimate Splat Biological Coefficient of Variation parameters

Parameters are estimated using the estimateDisp function in the edgeR package.

Usage

splatEstBCV(counts, params)

Arguments

counts

counts matrix to estimate parameters from.

params

SplatParams object to store estimated values in.

Value

SplatParams object with estimated values.

Details

The estimateDisp function is used to estimate the common dispersion and prior degrees of freedom. See estimateDisp for details. When estimating parameters on simulated data we found a broadly linear relationship between the true underlying common dispersion and the edgR estimate, therefore we apply a small correction, disp = 0.1 + 0.25 * edgeR.disp.