A logistic function is used to form a relationship between the expression level of a gene and the probability of dropout, giving a probability for each gene in each cell. These probabilities are used in a Bernoulli distribution to decide which counts should be dropped.
splatSimDropout(sim, params)
| sim | SingleCellExperiment to add dropout to. |
|---|---|
| params | SplatParams object with simulation parameters. |
SingleCellExperiment with simulated dropout and observed counts.